Enzymatic agents have been used to rejuvenate skin since Ancient Egypt. Chemical peels came into dermatological practice in the late 1800s, when salicylic acid, resorcinol, phenol and trichloroacetic acid (TCA) were noted for their rejuvenation and brightening properties.1 Dermatologists have since experimented with different formulations and applications of chemical peels, publishing their results along the way. It was not long before chemical peels became a top choice among skin care professionals for achieving optimal skin health over the long term. There are some new trends underway, and next-generation acids have entered the scene. These new trends and acids have been combined with traditional peel methods and formulas to pave the way for esthetic professionals to customize powerful and long-term pro-youth results for clients. This article will delve into the new formulas and trends in chemical peels while addressing how peels can most effectively be used in the treatment room to enhance youthful results.